Many people take prescription or over-the-counter medications every day without realizing they may be quietly depleting essential nutrients in the body. While medications can be necessary and lifesaving, long-term use can sometimes interfere with nutrient absorption, metabolism, or excretion—potentially contributing to fatigue, muscle pain, digestive issues, weakened immunity, or slower healing.
Understanding these common nutrient depletions can help you have more informed conversations with your healthcare provider and support your health more proactively.
Acid-Reducing Medications (PPIs & H2 Blockers)
Examples: Omeprazole (Prilosec), Esomeprazole (Nexium), Famotidine (Pepcid)
These medications reduce stomach acid, which is essential for absorbing certain nutrients.
Commonly depleted nutrients:
- Vitamin B12
- Magnesium
- Calcium
- Iron
Why it matters: Low stomach acid can impair digestion and nutrient absorption, increasing the risk of fatigue, bone loss, and nerve issues over time.
Metformin (Type 2 Diabetes)
Commonly depleted nutrients:
- Vitamin B12
- Folate
Why it matters: Long-term B12 deficiency may contribute to numbness, tingling, balance problems, and fatigue—symptoms that can overlap with diabetic neuropathy.
Statins (Cholesterol-Lowering Medications)
Examples: Atorvastatin (Lipitor), Simvastatin (Zocor)
Commonly depleted nutrients:
- Coenzyme Q10 (CoQ10)
Why it matters: CoQ10 is vital for muscle and heart energy. Low levels may contribute to muscle pain, weakness, and fatigue commonly reported with statin use.
Oral Contraceptives
Commonly depleted nutrients:
- Vitamin B6
- Vitamin B12
- Folate
- Magnesium
- Zinc
Why it matters: These nutrients play roles in hormone balance, energy, mood regulation, and immune function. Depletion may contribute to headaches, mood changes, or low energy in some individuals.
NSAIDs (Non-Steroidal Anti-Inflammatory Drugs)
Examples: Ibuprofen (Advil), Naproxen (Aleve), Aspirin
Commonly depleted nutrients:
- Iron
- Folate
- Vitamin C
Why it matters: Chronic use may irritate the gut lining and increase the risk of small amounts of blood loss, contributing to iron deficiency and impaired healing.
Diuretics (Blood Pressure & Fluid Retention)
Examples: Hydrochlorothiazide, Furosemide (Lasix)
Commonly depleted nutrients:
- Potassium
- Magnesium
- Sodium
- Zinc
Why it matters: Electrolyte imbalances can lead to muscle cramps, weakness, heart rhythm issues, and fatigue.
Antibiotics
Commonly depleted nutrients:
- Vitamin K
- B vitamins
- Beneficial gut bacteria
Why it matters: Antibiotics can disrupt the gut microbiome, which plays a key role in nutrient production, immune function, and digestion.
Supporting Your Body While on Medications
If you take medications regularly, especially long-term, it may be helpful to:
- Eat a nutrient-dense, whole-food diet
- Support gut health with fiber and fermented foods
- Consider targeted supplementation only under professional guidance
- Monitor nutrient levels when appropriate
- Address symptoms early rather than dismissing them as “normal”
The Bottom Line
Medications can be essential—but they are not nutrient-neutral. Being aware of potential nutrient depletions allows you to take a more proactive role in your health, reduce side effects, and support optimal healing.
If you have questions about how your medications may be affecting your nutritional status, speak with your healthcare provider to determine the safest and most effective approach for your individual needs.
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